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Normally, repair crews (blood vessels, fibroblasts, macrophages etc) take time to arrive and fix the damage especially in low-traffic areas like tendons and ligaments that dont get much blood flow

This provides a biological basis for considering whether pharmacological GLP-1 therapies, which achieve much higher systemic levels, could also reach the joint and potentially have local effects. Additionally, scientists found that the level of GLP-1 hormone in the synovial fluid is directly tied to the levels in the blood of arthritis patients

Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload

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